Why psilocybin's risks are so understudied

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I live in Colorado, where psilocybin – widely known as magic mushrooms – is easy to come by. Teens access it through illicit means from peers and other murky “sources.” Edible versions show up in chocolate bars wrapped in silver and gold foil with evocative names at smoke shops. You arrive late and stressed out to a friend’s house for an event, and they offer you a “microdose” of psilocybin.

To say psilocybin is everywhere and vastly underregulated is an understatement – it’s a serious problem. So when I received a pitch on how the popularity of and access to psilocybin is far outpacing the science and regulations behind it, I jumped at the chance to bring the story to readers.

Hollis Karoly and Kent Hutchison, psychiatry researchers from the University of Colorado Anschutz Medical Campus, have studied the same trend with cannabis for more than a decade and are working to help fill in fundamental gaps in understanding of the benefits – and many risks – behind psilocybin use.

“In a largely unregulated market, and with few clear guidelines on safe use, consumers are left to simply figure it out on their own,” they write.

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Amanda Mascarelli

Senior Health and Medicine Editor

Psilocybin mushrooms contain numerous chemical compounds that researchers have not yet studied. Smitt/iStock via Getty Images Plus

Psilocybin mushrooms are going mainstream, but scientific research and regulation lag behind

Hollis Karoly, University of Colorado Anschutz Medical Campus; Kent Hutchison, University of Colorado Anschutz Medical Campus

Psilocybin falls into a regulatory gray zone, with strict limitations around how it can be studied. As a result, very little is known about its health risks, despite its surging popularity.

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